Table of Contents

July 2007
 
 
Page
EXECUTIVE SUMMARY
1
PLASMA COLLECTIONS
12
PLASMA FRACTIONATION
45
MARKET OVERVIEW
63
IMMUNE GLOBULIN MARKET
74
POLYVALENT INTRAVENOUS IMMUNE GLOBULIN (IVIG) MARKET
89
ALBUMIN MARKET
112
HEMOPHILIA CARE MARKET
123
FACTOR VIII MARKET
130
FACTOR IX MARKET
146
VON WILLEBRAND’S DISEASE MARKET
147
INHIBITOR MARKET
156
OTHER BLEEDING DISORDERS
161
ALPHA-1 ANTITRYPSIN MARKET
167
ANTITHROMBIN III MARKET
172
FIBRIN SEALANT MARKET
173
OTHER PLASMA PRODUCTS
176
DISTRIBUTION OF PLASMA PRODUCTS
180
PROFILES OF THE MAJOR FRACTIONATORS
195


List of Tables and Charts

 
Page
PLASMA COLLECTIONS & FRACTIONATION

Plasma Collections by Organization
Plasma Processed by the Fractionators
Plasma Collected and Exported—1988 to 2006
Number of Licensed Plasma Centers in the US
Export of Plasma from 1990 to 2009 (liters & Dollars)
Export of Plasma by Country of Destination in 2006
Export of Plasma from 1992 to 2006 in liters (Chart)
Price of Plasma exported from the U.S. - 1992 to 2006 (Chart)
Price of Source and Recovered Plasma in the U.S. 1986 to 2006
Price of Source and Recovered Plasma in the U.S. (Chart)
Estimated Plant Capacity & Throughput in 2006
15
16
17
19
35
36
37
38
43
44
45
 
PLASMA FRACTIONS MARKET

Plasma Fractions Market by Product from 1986 to 2006 ($MM)
U.S. Plasma Fractions Market by Company ($MM) in 2006
Market Shares by Company with Recombinant Products (Chart)
Market Shares by Company without Recombinant Products (Chart)
Product Mix by Major Company with Recombinant Products
Product Mix by Major Company without Recombinant Products

Product Mix without Recombinant Products (Chart)
Product Mix with Recombinant Products (Chart)
Product Mix in 1996 (Chart)
Market Growth 1991 – 2006 without Recombinant Prod. (Chart) 
Market History 1991 – 2006 with/without Rec. Products (Chart)
Market Shares by Company1996 – 2006 without Rec. Prod. (Chart)


51
52
53
54
55
56

57
58
59
60
61
62
 
IMMUNE GLOBULIN MARKET

Polyvalent Intramuscular, Rho(D), Tetanus and Hepatitis B
Rabies, Other Immune Globulins and Summary – 2006
Polyvalent IGIV Market in the U.S. in 2006
Sales History by Company ($MM)
IVIG Sales 1991 - 2006 in Units (Chart)
IVIG Sales 1991 – 2006 in Dollars (Chart)
Market Shares by Company 1996 - 2006 (Chart)
Sales History (Units & Dollars)
Average Selling Price of IGIV


77
78
84
85
86
87
88
93
100

 
ALBUMIN MARKET

Albumin Market in Dollars, Units & Market Shares - 2006
Albumin Sales by Company, 1986 - 2006 in Dollars
Albumin Sales 1991 - 2006 in Units (12.5 grams) (Chart)
Albumin Sales 1991 – 2006 in Dollars (Chart)
S
ales History 1996 - 2006 (Market Shares by Company) (Chart)

107
108
109
110
111
 
FACTOR VIII MARKET

Acquisition Prices of Clotting Factors 2001 - 2006
Factor VIII Market in Dollars, Units & Market Shares in 2006
Factor VIII Market by Company from 1996 to 2006 ($MM)
Factor VIII Market by Company from 1995 to 2006 (Units MM)
Factor VIII Market Conversion from 1994 to 2006
Factor VIII Sales 1996 - 2006 in Units, Recomb./Plasma (Chart)
Factor VIII Sales 1995 - 2006 in Dollars, Recomb./Plasma (Chart) 
Market Shares by Company 1994 to 2006 (Chart)
Factor VIII & von Willebrand Disease Mkt. Shares - 2006 (Chart)
Factor VIII Market 1991 – 2006 in Dollars (Chart)
Acquisition Prices of Factor VIII Concentrate  1980 - 2006

133
136
137
138
139
140
141
142
143
144
145
 
FACTOR IX MARKET

Sales in Dollars, Units & Market Shares – 2006
Factor IX Market by Company, 1996 - 2006 ($MM)
Factor IX Market in International Units from 1986 to 2006
Factor IX Price per Unit, 1986 - 2006 (Plasma-derived only)
Market Shares by Company (Chart)
Market Shares by Company from 1986 to 2006 (Chart)
150
151
152
153
154
155
 
VON WILLEBRAND MARKET

Von Willebrand Market in Dollars, Units & Mkt. Shares - 2006

156
 
INHIBITOR CARE MARKET

Inhibitor Care Market by Product from 1986 to 2006 
Factors VIII and IX Concentrate’s Use in Immune Tolerance 
Inhibitor Care Market by Product & Therapy - 2006
Anti-Inhibitor (Bypassing Factors) Agents Market - 2006

162
164
165
166
 
OTHER PLASMA PRODUCTS MARKET

Alpha I Antitrypsin Market from 1996 to 2006 ($MM)
Antithrombin III Market by Company from 1998 to 2006 ($MM)
Alpha I Antitrypsin, Antithrombin III, and Fibrin Sealant Market in Dollars, Units & Market Shares

170
173

179
 


 

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